News

Sleep disturbances and epilepsy, which affect about 80 percent of pediatric Angelman syndrome patients, improve over the years, new Italian study shows. The study, “Epilepsy and sleep disorders improve in adolescents and adults with Angelman syndrome: A multicenter study on 46 patients,” appeared in the journal…

A global online Angelman syndrome registry that Australian researchers started in September 2016 has researched a critical mass, its founders report. Two hundred eighty-six people joined the registry in its first eight months. That number should not only help facilitate research but also help scientists identify patients who might want…

An analysis of the most common causes of hospitalization among patients with Angelman syndrome reveals that they differ based on age and gender. The study, published in the Journal of Applied Research in Intellectual Disabilities, shows common healthcare needs among sub-groups of Angelman patients, which may help design tailored…

Researchers identified differences in Angelman Syndrome (AS) symptoms across different strains of mice with AS. This work paves the way to finding the best mouse model for testing drugs to treat seizures and other deficiencies in AS. The study, “Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal…

Agilis Biotherapeutics presented a talk at the 2017 Angelman Syndrome Foundation Research Symposium and Family Conference about adeno-associated virus (AAV) mediated strategies for the treatment of Angelman syndrome (AS). Agilis, the biotech advancing DNA therapeutics for rare genetic diseases that affect the central nervous system (CNS), was…

Sleep problems of children with Angelman syndrome (AS) take a toll on parents as well, according to a study that takes a closer look at those challenges than previous research. The findings of the study, which was based on interviews with parents, prompted the research team to call for ways to…

Using a process called imprinting, researchers at Howard Hughes Medical Institute have discovered a new mechanism that cells use to control which genes are turned off during fetal development. The finding adds new knowledge to the underling mechanisms of developmental and neurological disorders, such as Angelman syndrome or Beckwith-Wiedemann…

A specific frequency of brain rhythms detected in electroencephalograms (EEG), called delta oscillations, may serve as a valuable biomarker for Angelman syndrome, a new study says. According to researchers, delta anomalies are increased in the brain of children with Angelman syndrome, and occur both when…

Researchers from the University of Connecticut School of Medicine have turned stem cells from patients with Angelman syndrome into neurons to investigate how the disease affects these cells. The neurons had faulty maturation and electrical activity, as well as decreased ability to communicate with each other.

Agilis Biotherapeutics is collaborating with the Gene Therapy Research Institution (GTRI) in Japan to develop and manufacture a new adeno-associated virus (AAV) gene therapy for Angelman syndrome (AS) and other rare genetic disorders. Angelman patients lack the maternal copy of the UBE3A gene. In certain brain areas, only…