Posts by: Jose Marques Lopes, PhD

News

Ovid Therapeutics is planning to start a pivotal Phase 3 trial of OV101 (gaboxadol), its investigational oral therapy, in children ages 4-12 with Angelman syndrome. The company’s decision is based ... Read more

August 10, 2018August 10, 2018

OV101 Safe, Well-tolerated, Shows Potential to Ease Symptoms in Angelman Patients, Phase 2 Results Suggest

News

Treatment candidate OV101 showed a favorable safety profile and was well-tolerated in adults and adolescents with Angelman syndrome in a Phase 2 trial, according to a press release from Ovid ... Read more

January 16, 2018January 16, 2018

Mutation Linked to Angelman Syndrome Activates Key Molecular Pathway in Brain Development, Study Finds

News

A mutation in the UBE3A gene, whose loss causes Angelman syndrome, activates a molecular pathway that is critical to brain development, new research shows. The study, “The autism-linked UBE3A ... Read more

January 9, 2018February 5, 2018

Special MRI Detects Oxidative Stress in the Brains of Angelman Syndrome Animal Models

News

A specific type of magnetic resonance imaging (MRI) can be used to detect oxidative stress in mouse models of Angelman syndrome and Alzheimer’s disease, new study shows. Hippocampus oxidative ... Read more

November 8, 2017November 8, 2017

Angelman Patients Frequently Have Gastrointestinal Problems, Study Finds

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Patients with Angelman syndrome (AS) often have gastrointestinal (GI) issues such as constipation, reflux and abnormal food-related behaviors, according to new research. The study, “Prevalence of gastrointestinal symptoms in ... Read more

October 31, 2017

Sleep Problems in Angelman Syndrome Start in Infancy, New Research Finds

News

Sleep problems in children with Angelman syndrome (AS), particularly abnormal nighttime duration and night-walking, start in early infancy, a new study shows. The research, “Sleep phenotypes in infants and ... Read more

October 3, 2017

Research on Mice Reveals Central Nervous System Alterations Increase Pain

News

In a mouse model of Angelman syndrome (AS), pain sensitivity increased due to genetic alterations in the central nervous system, new research from The University of North Carolina at ... Read more

September 26, 2017October 12, 2017

Sleep Disorders, Epilepsy Improve in Adolescents and Adults With Angelman Syndrome, Study Shows

News

Sleep disturbances and epilepsy, which affect about 80 percent of pediatric Angelman syndrome patients, improve over the years, new Italian study shows. The study, “Epilepsy and sleep disorders improve ... Read more

September 13, 2017

Parents of Children with Angelman Syndrome Outline How Their Youngsters’ Sleep Problems Affect Them

News

Sleep problems of children with Angelman syndrome (AS) take a toll on parents as well, according to a study that takes a closer look at those challenges than previous research. ... Read more

Posts by: Jose Marques Lopes, PhD

Jose Marques Lopes, PhD

Ovid Therapeutics to Start Phase 3 Trial of OV101 in Children with Angelman Syndrome

OV101 Safe, Well-tolerated, Shows Potential to Ease Symptoms in Angelman Patients, Phase 2 Results Suggest

Mutation Linked to Angelman Syndrome Activates Key Molecular Pathway in Brain Development, Study Finds

Special MRI Detects Oxidative Stress in the Brains of Angelman Syndrome Animal Models

Angelman Patients Frequently Have Gastrointestinal Problems, Study Finds

Sleep Problems in Angelman Syndrome Start in Infancy, New Research Finds

Research on Mice Reveals Central Nervous System Alterations Increase Pain

Sleep Disorders, Epilepsy Improve in Adolescents and Adults With Angelman Syndrome, Study Shows

Parents of Children with Angelman Syndrome Outline How Their Youngsters’ Sleep Problems Affect Them

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