Author Archives: Joana Fernandes, PhD

A specific frequency of brain rhythms detected in electroencephalograms (EEG), called delta oscillations, may serve as a valuable biomarker for Angelman syndrome, a new study says. According to researchers, delta anomalies are increased in the brain of children with Angelman syndrome, and occur both when…

Researchers from the University of Connecticut School of Medicine have turned stem cells from patients with Angelman syndrome into neurons to investigate how the disease affects these cells. The neurons had faulty maturation and electrical activity, as well as decreased ability to communicate with each other.

Roche and representatives of parent-driven organizations are collaborating on the first part of a study whose objective is to design better clinical trials and speed up the development of Angelman syndrome treatments. The aim of the initial part of the study is to gain a…

A recent review highlights the latest findings on the role of a group of molecules called long noncoding RNAs (lncRNAs) in neurodevelopmental disorders such as Angelman syndrome. The review, titled “Long noncoding RNA and its contribution to autism spectrum disorders,” was published in the journal CNS Neuroscience & Therapeutics.

ANAVEX 2-73 significantly reduced sound-triggered seizures in mice with Angelman syndrome, according to a preclinical-trial study. Its developer, Anavex Life Sciences, reported the results at the Antiepileptic Drug Trials XIV 2017 Conference  in North Miami Beach, May 17-19. The presentation was titled “ANAVEX 2-73,…