News

Complications with scoliosis surgery common for Angelman patients

Spinal surgery for scoliosis carries a high likelihood of complications, including serious ones, among people with Angelman syndrome and a related disorder known as Prader-Willi syndrome, a study highlights. “These findings provide additional evidence to support the idea that surgical intervention in patients with scoliosis with underlying AS [Angelman…

Angelman gene therapy is made for preclinical-clinical translation

Because antisense oligonucleotide (ASO) therapies target specific genetic sequences, differences across mammals make it challenging to translate potential Angelman ASO-based therapies from preclinical models to the clinic. GTX-102, an investigational ASO therapy for Angelman syndrome, was specifically designed to be effective in patients and relevant animal models, however.

Sleep duration, quality improves with behavioral intervention

A tailored behavioral intervention program led to longer sleep time, better sleep habits, and improved quality of life in children with Angelman syndrome, a Dutch study reports. The findings suggest “behavioral intervention has a positive and persistent effect on sleep problems in children with AS [Angelman symdrome],” the researchers…

Severe seizure events found to be common in Angelman patients

Severe seizure events known as status epilepticus are common in people with Angelman syndrome, especially during childhood, a new review study found. Researchers noted that status epilepticus often causes subtle symptoms that may be overlooked by caregivers and clinicians, highlighting the importance of correctly identifying and promptly treating these…

International Angelman Day to be observed on Feb. 15

Organizations around the world will come together Feb. 15 to observe International Angelman Day (IAD), a global effort to raise awareness, honor those living with the rare neurological disease and commemorate those who have passed away. The annual initiative also seeks to encourage fundraising and support research for…