Angelman Symptoms Linked to Loss of Ube3a Gene in Specific Nerve Cells, Mouse Study Suggests

Loss of the maternal copy of the UBE3a gene in a specific set of nerve cells called GABAergic neurons is a key factor underlying Angelman syndrome, a mouse study suggests. The study, “GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility,” was published in the…

Touchscreen Test for Mice with Angelman Syndrome May Help Identify Their Cognitive Impairment

University of California researchers have developed a touchscreen test for mice with Angelman syndrome that they believe will shed additional light on learning disabilities stemming from the disease. It is one of a batteries of tests they are giving the animals to obtain a greater understanding of Angelman’s effect on…