News

The melatonin secretion profile of patients with Angelman syndrome is impaired, leading to a variety of sleep problems, a new study shows. The study, “Melatonin and Angelman syndrome – implications and mathematical model of diurnal secretion,” was published in the International Journal of Endocrinology. Sleep disturbances…

A group of designers from around the world will be showcasing their latest designs on April 28, 2018, in New York City while the Foundation for Angelman Syndrome Therapeutics (FAST) raises funds to support research for a cure for Angelman syndrome (AS). Credit: Katherine Angelique…

In rare cases, loss of part of the UBE3A gene can lead to Angelman syndrome, Spanish researchers report. The team at the Autonomous University of Barcelona based their conclusion on a case study of two children with Angelman features. Their work added to the little knowledge there is about gene deletions causing…

Ovid Therapeutics will modify its ongoing Phase 2 trial of OV101 to add adolescents with Angelman syndrome aged 13 and older to the adults it continues to recruit. The decision came after a Phase 1 trial showed that adolescents process the drug the same way adults do, suggesting it…

Ovid Therapeutics presented data from several studies that support the clinical development of the investigational therapy TAK-935/OV935 as a potential treatment for developmental and epileptic encephalopathies. These results are particularly significant for Angelman syndrome patients, 85 percent of whom suffer from some form of epilepsy. The findings from…

This year’s FAST Summit & Gala in Chicago generated a record $4.1 million for Angelman syndrome research — more than triple the $1.3 million raised at the 2016 gala. Colin Farrell and other Hollywood stars who attended the dinner on Dec. 2 helped attract nearly 1,300 people to the two-day…

Karen Haberberg, a New York portrait photographer, has taken tens of thousands of pictures throughout her career of families, couples, pregnant women, teenagers, and fashion models — not to mention dramatic landscape shots from Iceland to Indonesia. She’s also done several personal photo projects, including “Benjamin,” a haunting portrayal…

Ovid Therapeutics is recruiting adult patients with Angelman syndrome to a Phase 2 clinical trial of gaboxadol, a compound that aims to treat the disease by restoring lost inhibitory brain signaling. The study, which is running in a number of U.S. clinics and Israel, aims to recruit 75 patients…

Machine learning methods could improve the ability of clinical trials to detect if treatments targeting the brain — such as for Angelman syndrome — are effective, as these methods are more sensitive to change than traditional statistical tests, say researchers from University College London. Such methods could solve the problem…

The successful development of meaningful therapies for rare diseases such as Angelman syndrome requires scientists to find out what matters most to patients with these conditions, two European researchers argued in an opinion piece promoting patient-centered outcomes. In the commentary, published in the Orphanet Journal of Rare Diseases, the…